| Autor: |
Skurikhin EG; Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; Scientific Future Management, Novosibirsk, Russia. ovpershina@gmail.com., Ermakova NN, Reztsova AM, Pershina OV, Khmelevskaya ES, Krupin VA, Stepanova IE, Reztsova VM, Reihard DV, Artamonov AV, Bekarev AA, Madonov PG, Kinsht DN, Goldberg VE, Dygai AM |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Nov; Vol. 156 (1), pp. 53-8. |
| DOI: |
10.1007/s10517-013-2276-0 |
| Abstrakt: |
The possibility of boosting antifibrotic activity of testicular hyaluronidase immobilized on polyethylene oxide with spiperone was studied on the bleomycin models of a single (partially reversible pneumofibrosis) and repeated (irreversible pneumofibrosis) injuries to the alveolar epithelium in C57Bl/6 mice. The antifibrotic effect was more pronounced after successive treatment with immobilized hyaluronidase and spiperone than after individual treatment with each of the compounds: no collagen deposition in the parenchyma of bleomycin-damaged lungs was found. The decrease in inflammatory cell (lymphocytes, macrophages, neutrophils, plasma cells) infiltration of the alveoli and alveolar tracts interstitium in mice treated by immobilized hyaluronidase and spiperone did not differ from the anti-inflammatory effect of spiperone monotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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