| Autor: |
Gonotkov MA; Komi Research Institute of Physiology, Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia. golovko@physiol.komisc.ru., Golovko VA |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Nov; Vol. 156 (1), pp. 4-6. |
| DOI: |
10.1007/s10517-013-2263-5 |
| Abstrakt: |
Duration of the plateau phase (phase 2) of action potentials in pacemaker cells in mouse sinoatrial node characterized by low upstroke rate during the rapid depolarization (dV/dt max <7 V/sec, phase 0) and in atrial-like cells with dV/dt max <100 V/sec were prolonged by 50% with 4-aminopyridine in concentrations of 0.7 and 0.1 mM, respectively. This blocker did not lengthen the terminal repolarization (phase 3). The above changes were accompanied by a 20-80% decrease in dV/dt max in comparison to the control. It is hypothesized that the short-term (transient) outward current Ito takes a part in the plateau formation and modulates the duration of the rapid depolarization phase of action potentials in mouse sinoatrial node cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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