Phytochemical Screening and Anti-nociceptive Properties of the Ethanolic Leaf Extract of Trema Cannabina Lour.
| Autor: | Hossain H; BCSIR Laboratories, Dhaka, Bangladesh Council of Scientific and Industrial Research, Dhaka-1205, Bangladesh., Jahan IA, Islam HS, Kanti DS, Arpona H, Arif A |
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| Jazyk: | angličtina |
| Zdroj: | Advanced pharmaceutical bulletin [Adv Pharm Bull] 2013; Vol. 3 (1), pp. 103-8. Date of Electronic Publication: 2013 Feb 07. |
| DOI: | 10.5681/apb.2013.017 |
| Abstrakt: | Purpose: The present study was designed to investigate the anti-nociceptive activity of ethanolic leaf extract of Trema cannabina Lour (family: Cannabaceae) in experimental animal models. Methods: The anti-nociceptive action was carried out against two types of noxious stimuli, thermal (hot plate and tail immersion tests) and chemical (acetic acid-induced writhing) in mice. Results: Phytochemical analysis of crude extract indicated the presence of reducing sugar, tannins, steroid and alkaloid types of secondary metabolites. Crude extract of T. cannabina (500 mg/kg dose) showed maximum time needed for the response against thermal stimuli (6.79±0.15 seconds) which is comparable to diclofenac sodium (8.26±0.14 seconds) in the hot plate test. Hot tail immersion test also showed similar results as in hot plate test. At the dose of 250 and 500 mg/kg body weight, the extract showed significantly and in a dose-dependent (p<0.001) reduction in acetic acid induced writhing in mice with a maximum effect of 47.56% reduction at 500 mg/kg dose comparable to that of diclofenac sodium (67.07%) at 25 mg/kg. Conclusion: The obtained results tend to suggest the Anti-nociceptive activity of ethanolic leaf extract of Trema cannabina and thus provide the scientific basis for the traditional uses of this plant part as a remedy for pain. |
| Databáze: | MEDLINE |
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