Mindfulness-based cognitive therapy for preventing relapse in recurrent depression: a randomized dismantling trial.

Autor:	Williams JM; Department of Psychiatry, University of Oxford., Crane C; Department of Psychiatry, University of Oxford., Barnhofer T; Department of Psychiatry, University of Oxford., Brennan K; Department of Psychiatry, University of Oxford., Duggan DS; Department of Psychiatry, University of Oxford., Fennell MJ; Department of Psychiatry, University of Oxford., Hackmann A; Department of Psychiatry, University of Oxford., Krusche A; Department of Psychiatry, University of Oxford., Muse K; Department of Psychiatry, University of Oxford., Von Rohr IR; Department of Psychiatry, University of Oxford., Shah D; Department of Psychiatry, University of Oxford., Crane RS; Centre for Mindfulness Research and Practice, Bangor University., Eames C; Centre for Mindfulness Research and Practice, Bangor University., Jones M; Centre for Mindfulness Research and Practice, Bangor University., Radford S; Centre for Mindfulness Research and Practice, Bangor University., Silverton S; Centre for Mindfulness Research and Practice, Bangor University., Sun Y; North Wales Organisation for Randomised Trials in Health (NWORTH), Bangor University., Weatherley-Jones E; Centre for Mindfulness Research and Practice, Bangor University., Whitaker CJ; North Wales Organisation for Randomised Trials in Health (NWORTH), Bangor University., Russell D; College of Medicine, Swansea University., Russell IT; College of Medicine, Swansea University.
Jazyk:	angličtina
Zdroj:	Journal of consulting and clinical psychology [J Consult Clin Psychol] 2014 Apr; Vol. 82 (2), pp. 275-86. Date of Electronic Publication: 2013 Dec 02.
DOI:	10.1037/a0035036
Abstrakt:	Objective: We compared mindfulness-based cognitive therapy (MBCT) with both cognitive psychological education (CPE) and treatment as usual (TAU) in preventing relapse to major depressive disorder (MDD) in people currently in remission following at least 3 previous episodes. Method: A randomized controlled trial in which 274 participants were allocated in the ratio 2:2:1 to MBCT plus TAU, CPE plus TAU, and TAU alone, and data were analyzed for the 255 (93%; MBCT = 99, CPE = 103, TAU = 53) retained to follow-up. MBCT was delivered in accordance with its published manual, modified to address suicidal cognitions; CPE was modeled on MBCT, but without training in meditation. Both treatments were delivered through 8 weekly classes. Results: Allocated treatment had no significant effect on risk of relapse to MDD over 12 months follow-up, hazard ratio for MBCT vs. CPE = 0.88, 95% CI [0.58, 1.35]; for MBCT vs. TAU = 0.69, 95% CI [0.42, 1.12]. However, severity of childhood trauma affected relapse, hazard ratio for increase of 1 standard deviation = 1.26 (95% CI [1.05, 1.50]), and significantly interacted with allocated treatment. Among participants above median severity, the hazard ratio was 0.61, 95% CI [0.34, 1.09], for MBCT vs. CPE, and 0.43, 95% CI [0.22, 0.87], for MBCT vs. TAU. For those below median severity, there were no such differences between treatment groups. Conclusion: MBCT provided significant protection against relapse for participants with increased vulnerability due to history of childhood trauma, but showed no significant advantage in comparison to an active control treatment and usual care over the whole group of patients with recurrent depression.
Databáze:	MEDLINE
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