| Autor: |
Chavkin C; Department of Pharmacology, University of Washington, Seattle, WA, 98195, USA, cchavkin@u.washington.edu., Schattauer SS, Levin JR |
| Jazyk: |
angličtina |
| Zdroj: |
Handbook of experimental pharmacology [Handb Exp Pharmacol] 2014; Vol. 219, pp. 281-92. |
| DOI: |
10.1007/978-3-642-41199-1_14 |
| Abstrakt: |
Studies of kappa opioid receptor signaling mechanisms during the last decade have demonstrated that agonist activation of the receptor results in Gβγ-dependent signaling and distinct arrestin-dependent signaling events. Gβγ-dependent signaling results in ion channel regulation causing neuronal inhibition, inhibition of transmitter release, and subsequent analgesic responses. In contrast, arrestin-dependent signaling events result in p38 MAPK activation and subsequent dysphoric and proaddictive behavioral responses. Resolution of these two branches of signaling cascades has enabled strategies designed to identify pathway-selective drugs that may have unique therapeutic utilities. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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