| Autor: |
Ohba S; Department of Bioengineering, The University of Tokyo Graduate School of Engineering, Japan., Chung UI, Tei Y |
| Jazyk: |
japonština |
| Zdroj: |
Clinical calcium [Clin Calcium] 2013 Dec; Vol. 23 (12), pp. 1723-9. |
| DOI: |
CliCa131217231729 |
| Abstrakt: |
Mammalian skeletons are formed through two distinct processes, intramembranous ossification and endochondral ossification. During the endochondral ossification, indian hedgehog (Ihh) /parathyroid hormone-related protein (PTHrP) negative-feedback loop regulates the distance between epiphysis and the layer of hypertrophic chondrocytes. Ihh also stimulates bone formation. Based on such knowledge, bioactive molecule-loaded artificial bones are expected to achieve efficient bone regeneration without cell transplantation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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