| Autor: |
Aseychev AV; Laboratory of Biophysical Bases of Pathology, Research Institute of Physicochemical Medicine, Russian Federal Medical Biological Agency, Moscow, Russia. aseychev@mail.ru., Azizova OA, Beckman EM, Dudnik LB, Sergienko VI |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2013 Sep; Vol. 155 (5), pp. 685-8. |
| DOI: |
10.1007/s10517-013-2226-x |
| Abstrakt: |
We studied the effect of gold nanospheres coated with components of autologous blood plasma on ADP-induced platelet aggregation. Gold nanoparticles in the chosen concentration range (5-40 μM) and particle size (5-30 nm) with or without coating produced no activating effect on platelet aggregation caused by aggregation inductor ADP in all applied doses (1.6, 2.0, and 5.0 μM). Nanoparticles with a diameter of >60 nm inhibited platelet aggregation. These findings and published data confirm the biological safety of gold nanoparticles for targeted delivery of drugs and phototherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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