| Autor: |
van Bohemen CG, Nabbe AJ, Landheer JE, Grumet FC, Mazurkiewicz ES, Dinant HJ, Lionarons RJ, van Bodegom PC, Zanen HC |
| Jazyk: |
angličtina |
| Zdroj: |
Immunology letters [Immunol Lett] 1986 Aug; Vol. 13 (1-2), pp. 71-4. |
| DOI: |
10.1016/0165-2478(86)90128-8 |
| Abstrakt: |
The heterogeneous HLA-B27 antigen is closely associated with post-infectious or reactive arthritis (ReA) and is comprised of two serologically defined variants: B27M1+M2+ and B27M1+M2-. An outbreak of dysentery (n = 120) caused by a Shigella flexneri 2a strain, which possessed cell envelope antigens with epitopes resembling B27M2, resulted in five B27M1+M2+ patients with ReA. The remaining seven B27M1+M2+, one B27M1+M2- and all but three B27-negative patients remained free of joint symptoms; the latter three displayed arthralgia. IgM, IgG and IgA serum titers were statistically raised in all patient groups, but were exceptionally and persistently high in the B27M1+M2+ patients with ReA, especially IgA, as determined in acute-phase sera and sera sampled 1 year after dysentery. B27M1+M2+ thus appears to be a marker for a subset of disease, characterized by a high immune response. It is concluded that the B27M2 epitope is not unequivocally disease-related to Shigella ReA, that B27M1+M2+ is not likely to be the only immune-response-regulating gene involved in this form of ReA and that cross-reactivity between bacterial antigenic epitopes and B27 can only be part of a multifactorial process leading to ReA and in itself not sufficient to produce ReA. The intensity of the immune response appears to be another important factor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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