DNA methylation reprogramming in cancer: does it act by re-configuring the binding landscape of Polycomb repressive complexes?

Autor: Reddington JP; MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, United Kingdom., Sproul D, Meehan RR
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2014 Feb; Vol. 36 (2), pp. 134-40. Date of Electronic Publication: 2013 Nov 26.
DOI: 10.1002/bies.201300130
Abstrakt: DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer-associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the Polycomb system is responsible for the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis-targeting could directly drive carcinogenesis and disease progression.
(© 2014 The Authors. Bioessays published by WILEY Periodicals, Inc.)
Databáze: MEDLINE
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