| Autor: |
Hall IH; Division of Medicinal Chemistry, School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27514., Wyrick SD, Voorstad PJ, Dubey A |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmaceutical research [Pharm Res] 1984 Jan; Vol. 1 (1), pp. 28-32. |
| DOI: |
10.1023/A:1016326625380 |
| Abstrakt: |
N-(p-Chlorobenzoyl)-sulfamate was observed to produce potent hypolipidemic activity in rodents at 10 to 60 mg/kg/day. Liver phosphatidate phosphohydrolase and sn-glycerol-3-phosphate acyl transferase activities were suppressed by the agent in vitro and in vivo, and ATP dependent citrate lyase and acetyl CoA carboxylase activities were reduced in vivo. N-(p-Chlorobenzoyl)-sulfamate reduced cholesterol, neutral lipids, and triglycerides in the liver and increased excretion of cholesterol and neutral lipids in the bile and feces. Drug treatment reduced the neutral lipid and triglyceride content of serum chylomicrons, VLDL and LDL, and cholesterol content was reduced in the chylomicron and HDL fractions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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