| Autor: |
Ottenhoff TH, Torres P, de las Aguas JT, Fernandez R, van Eden W, de Vries RR, Stanford JL |
| Jazyk: |
angličtina |
| Zdroj: |
Lancet (London, England) [Lancet] 1986 Aug 09; Vol. 2 (8502), pp. 310-3. |
| DOI: |
10.1016/s0140-6736(86)90004-8 |
| Abstrakt: |
Antigens of Mycobacterium tuberculosis, M leprae, M scrofulaceum, and M vaccae were injected intradermally in 86 caucasoid leprosy patients, and skin responses (measured in mm of induration at 72 h) were analysed in relation to HLA class II phenotypes. HLA-DR4 was associated with high responsiveness to antigens specific to M tuberculosis but not to antigens shared with other mycobacteria (p = 0.0005). Because DR4 is associated with rheumatoid arthritis (RA) and because a role for M tuberculosis antigens has been suggested both in experimentally induced autoimmune arthritis in rats and in RA, the DR4 associated regulation of the immune response to M tuberculosis may be relevant to the pathogenesis of RA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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