Diterpenoid alkaloids and flavonoids from Delphinium trichophorum.

Autor: Lin CZ; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China., Zhao ZX; School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Xie SM; School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Mao JH; School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Zhu CC; Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, PR China. Electronic address: zhuchenchen@vip.sina.com., Li XH; School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Zeren-dawa B; Tibetan Traditional Medical College, Lasa 850000, PR China., Suolang-qimei K; Tibetan Traditional Medical College, Lasa 850000, PR China., Zhu D; Tibetan Traditional Medical College, Lasa 850000, PR China., Xiong TQ; School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China., Wu AZ; School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2014 Jan; Vol. 97, pp. 88-95. Date of Electronic Publication: 2013 Nov 17.
DOI: 10.1016/j.phytochem.2013.10.011
Abstrakt: Five hetisane-type C20-diterpenoid alkaloids, trichodelphinines A-E, one delnudine-type C20-diterpenoid alkaloid, trichodelphinine F and three known flavonoids, quercetin, quercetin 3-O-β-D-glucopyranoside, and quercetin 3-O-β-D-glucopyranoside-7-O-α-L-arabinopyranoside, were isolated from whole plants of Delphinium trichophorum Franch. Their structures were elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC, (1)H-(1)H COSY, NOESY and X-ray crystallographic analysis, and from chemical evidence. The cytotoxic activities of the diterpenoid alkaloids were evaluated using the MTT method, and the IC50 values of their cytotoxicity against A549 cancer cells ranged from 12.03 to 52.79 μM.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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