| Autor: |
Fujiwara T; Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan ; Molecular Hematology/Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan., Okitsu Y, Katsuoka Y, Fukuhara N, Onishi Y, Ishizawa K, Harigae H |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS open bio [FEBS Open Bio] 2013 Oct 11; Vol. 3, pp. 428-32. Date of Electronic Publication: 2013 Oct 11 (Print Publication: 2013). |
| DOI: |
10.1016/j.fob.2013.10.004 |
| Abstrakt: |
ETO2 is a component of a protein complex containing master regulators of hematopoiesis, including GATA-1 and SCL/TAL1, and also has RNA binding properties. Although ETO2 has been reported to repress GATA-1 target genes through histone deacetylation of the target gene loci in erythroid cells, little is known about the contribution of ETO2 to microRNA (miRNA) regulation. Here, we conducted miRNA profiling in ETO2-overexpressing and ETO2-silenced K562 cells. The analysis suggests that ETO2 positively regulates the abundance of mature miRNAs, including miR-21, miR-29b and let-7e. Our data suggest a novel mode of ETO2-mediated target gene repression via effects on miRNA expression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text