Epstein-Barr virus-positive oral ulceration simulating Hodgkin lymphoma in a patient treated with methotrexate: case report and review of the literature.
| Autor: | Naidu A; Assistant Professor, Department of Diagnostic Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX. Electronic address: anaidu@bcd.tamhsc.edu., Kessler HP; Professor, Department of Diagnostic Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX., Pavelka MA; Clinical Professor, Department of Oral and Maxillofacial Surgery, Texas A&M University Baylor College of Dentistry, Dallas, TX. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons [J Oral Maxillofac Surg] 2014 Apr; Vol. 72 (4), pp. 724-9. Date of Electronic Publication: 2013 Nov 15. |
| DOI: | 10.1016/j.joms.2013.09.013 |
| Abstrakt: | Immunosuppressive therapy for patients diagnosed with rheumatoid arthritis has long been implicated in the development of various neoplastic processes, including leukemia and lymphoma. Methotrexate is a commonly administered antimetabolic medication thought to improve the symptoms of rheumatoid arthritis through its anti-inflammatory effects. Longterm methotrexate therapy and concurrent rheumatoid arthritis have both been independently suggested as risk factors for developing lymphoma. The mechanism has been theorized to be severe immunosuppression and an increased frequency of latent infection with pro-oncogenic viruses, such as the Epstein-Barr virus (EBV). Spontaneous remission of these malignancies has been seen after discontinuation of the methotrexate therapy. In the present study, we report the case of a patient diagnosed with rheumatoid arthritis and treated with methotrexate and prednisone. She developed intraoral ulcerations that histopathologically resembled Hodgkin's lymphoma. (Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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