Iloprost reduces colitis induced oxidative stress: An experimental study in rats.
| Autor: | Aytaç E; İstanbul University Cerrahpaşa Medical Faculty, Department of General Surgery, İstanbul, Turkey., Teksöz S, Saygılı S, Tortum OB, Yavuz N, Sözer V, Göksel S, Uzun H, Seymen HO, Göksoy E |
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| Jazyk: | angličtina |
| Zdroj: | The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2013; Vol. 24 (3), pp. 224-9. |
| DOI: | 10.4318/tjg.2013.0491 |
| Abstrakt: | Background/aims: Reactive oxygen species have a known potent role in the pathogenesis of ulcerative colitis. Iloprost, a pharmaceutical, is a chemically stable derivative of a naturally- occurring human prostacyclin. Several studies have demonstrated protective effects of iloprost via its antioxidant and its anti-inflammatory activity. The aim of this study is to evaluate the effects of iloprost on oxidant/antioxidant status, as well as the large bowel histopathology in experimental colitis. Materials and Method: Forty adult male Wistar-albino rats were randomly divided in to four equal weight-matched groups: sham group (n=10), iloprost administered sham group (n=10), colitis group (n=10), iloprost administered colitis group (n=10). Acetic acid (1 ml of 4% solution) was used to induce colonic inflammation in the rats. Results: Colonic tissue and plasma malondialdehyde levels were significantly lower in the iloprost administered colitis group than the colitis group (p<0.01). Tissue glutathione levels of the iloprost administered colitis group were significantly higher than the colitis group (p<0.001). Conclusion: We have demonstrated in this study iloprost to be an antioxidant, as well as iloprost demonstrating protective activity against colitis induced oxidative stress. |
| Databáze: | MEDLINE |
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