| Autor: |
Meuwese JD; Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands ; Cognitive Science Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands., van Loon AM, Scholte HS, Lirk PB, Vulink NC, Hollmann MW, Lamme VA |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2013 Nov 01; Vol. 8 (11), pp. e79326. Date of Electronic Publication: 2013 Nov 01 (Print Publication: 2013). |
| DOI: |
10.1371/journal.pone.0079326 |
| Abstrakt: |
Recurrent interactions between neurons in the visual cortex are crucial for the integration of image elements into coherent objects, such as in figure-ground segregation of textured images. Blocking N-methyl-D-aspartate (NMDA) receptors in monkeys can abolish neural signals related to figure-ground segregation and feature integration. However, it is unknown whether this also affects perceptual integration itself. Therefore, we tested whether ketamine, a non-competitive NMDA receptor antagonist, reduces feature integration in humans. We administered a subanesthetic dose of ketamine to healthy subjects who performed a texture discrimination task in a placebo-controlled double blind within-subject design. We found that ketamine significantly impaired performance on the texture discrimination task compared to the placebo condition, while performance on a control fixation task was much less impaired. This effect is not merely due to task difficulty or a difference in sedation levels. We are the first to show a behavioral effect on feature integration by manipulating the NMDA receptor in humans. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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