Synthesis and antimicrobial activity of α-aminoboronic-containing peptidomimetics.
| Autor: | Gozhina OV; Department of Chemistry, University of Tromsø, Tromsø, Norway., Svendsen JS, Lejon T |
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| Jazyk: | angličtina |
| Zdroj: | Journal of peptide science : an official publication of the European Peptide Society [J Pept Sci] 2014 Jan; Vol. 20 (1), pp. 20-4. Date of Electronic Publication: 2013 Nov 13. |
| DOI: | 10.1002/psc.2583 |
| Abstrakt: | A library of 175 dipeptidomimetics and tripeptidomimetics containing an α-amino boronic acid or boronate has been synthesized, and the activity toward Mycobacterium tuberculosis, Candida albicans, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa has been screened. Although there is no clear structure-activity relationship, several compounds exhibit promising activity against different pathogens. (Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd.) |
| Databáze: | MEDLINE |
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