Heart transplantation in pediatric cardiomyopathies.

Autor: Birnbaum BF; Washington University in St. Louis and St. Louis Children's Hospital, 1 Children's Place Box 8116, St. Louis, MO 63110, USA., Simpson KE, Canter CE
Jazyk: angličtina
Zdroj: Expert review of cardiovascular therapy [Expert Rev Cardiovasc Ther] 2013 Dec; Vol. 11 (12), pp. 1677-90.
DOI: 10.1586/14779072.2013.847789
Abstrakt: Cardiomyopathies represent an uncommon but serious cause of heart disease in the pediatric population and can be categorized as dilated, hypertrophic, restrictive and left ventricular non-compaction. Each of these subtypes has multiple potential genetic etiologies in addition to possible non-genetic causes. Many patients with cardiomyopathies can benefit from transplantation, although there is not insignificant morbidity and mortality for those patients. Outcomes both prior to and following transplantation depend on the underlying etiology, the amount of support needed prior to transplantation and the illness severity of the patient prior to transplantation. Mechanical circulatory support is frequently used to bridge patients to transplantation, and newer technologies are currently in development.
Databáze: MEDLINE