| Autor: |
Rigoli JW; Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States., Weatherly CD, Alderson JM, Vo BT, Schomaker JM |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Chemical Society [J Am Chem Soc] 2013 Nov 20; Vol. 135 (46), pp. 17238-41. Date of Electronic Publication: 2013 Nov 11. |
| DOI: |
10.1021/ja406654y |
| Abstrakt: |
Organic N-containing compounds, including amines, are essential components of many biologically and pharmaceutically important molecules. One strategy for introducing nitrogen into substrates with multiple reactive bonds is to insert a monovalent N fragment (nitrene or nitrenoid) into a C-H bond or add it directly to a C═C bond. However, it has been challenging to develop well-defined catalysts capable of promoting predictable and chemoselective aminations solely through reagent control. Herein, we report remarkable chemoselective aminations that employ a single metal (Ag) and a single ligand (phenanthroline) to promote either aziridination or C-H insertion by manipulating the coordination geometry of the active catalysts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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