Hyptis suaveolens (L.) Poit (Lamiaceae), a medicinal plant protects the stomach against several gastric ulcer models.

Autor: Jesus NZ; Department of Pharmaceutical Sciences, Federal University of Paraiba (UFPB), 58051-970 João Pessoa, PB, Brazil., Falcão HS, Lima GR, Caldas Filho MR, Sales IR, Gomes IF, Santos SG, Tavares JF, Barbosa-Filho JM, Batista LM
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2013 Dec 12; Vol. 150 (3), pp. 982-8. Date of Electronic Publication: 2013 Oct 29.
DOI: 10.1016/j.jep.2013.10.010
Abstrakt: Ethnopharmacological Relevance: Hyptis suaveolens is used by the traditional population in several parts of the world to treat inflammation, gastric ulcer and infection and is used as a crude drug to relieve symptoms related with gastric ulcer or gastritis in northeaster and central region of Brazil.
Materials and Methods: the standardized ethanolic extract (Hs-EtOHE) and hexanic fraction (Hs-HexF) of Hyptis suaveolens (62,5, 125, 250 and 500 mg/kg) was evaluated in several models of acute gastric ulcers. The participation of NO was evaluated by pretreatment with L-NAME and non-protein sulfyhydryls by NEM in the gastroprotective effect.
Results: Hs-EtOHE and Hs-HexF markedly reduced the gastric lesions induced by all ulcerogenic agents (HCl/ethanol, ethanol, NSAIDs and hypothermic restraint-stress). Gastric ulcerations were exacerbated by administration of NEM suggesting that the gastroprotective mechanism of action of Hs-EtOHE and Hs-HexF involves sulfhydryl groups.
Conclusion: Ours results show that an extract of Hyptis suaveolens, administered orally to rodents, present gastro protective activity in different models of acute of gastric ulcer and give some support to the reported claims on the use of this plant as a gastro protective agent.
(© 2013 Published by Elsevier Ireland Ltd.)
Databáze: MEDLINE
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