Targeting mitochondrial DNA with a platinum-based anticancer agent.
| Autor: | Wisnovsky SP; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada., Wilson JJ, Radford RJ, Pereira MP, Chan MR, Laposa RR, Lippard SJ, Kelley SO |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biology [Chem Biol] 2013 Nov 21; Vol. 20 (11), pp. 1323-8. Date of Electronic Publication: 2013 Oct 31. |
| DOI: | 10.1016/j.chembiol.2013.08.010 |
| Abstrakt: | An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus. (Copyright © 2013 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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