High-grade endometrial cancer: revisiting the impact of tumor size and location on outcomes.

Autor: Doll KM; Division of Gynecologic Oncology, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA. Electronic address: kmdoll@med.unc.edu., Tseng J; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Greater Baltimore Medical Center/John Hopkins Hospital, Baltimore, MD, USA., Denslow SA; Health Research Group, LLC, Asheville, NC, USA., Fader AN; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Greater Baltimore Medical Center/John Hopkins Hospital, Baltimore, MD, USA., Gehrig PA; Division of Gynecologic Oncology, University of North Carolina, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Jazyk: angličtina
Zdroj: Gynecologic oncology [Gynecol Oncol] 2014 Jan; Vol. 132 (1), pp. 44-9. Date of Electronic Publication: 2013 Oct 29.
DOI: 10.1016/j.ygyno.2013.10.023
Abstrakt: Objective: Research on tumor size (TS) and intracavitary tumor location in endometrial cancer has focused primarily on low-grade tumors. Data in patients with high-grade histology are limited. Our goal is to determine if TS or lower uterine segment (LUS) involvement, is associated with nodal disease and recurrence in women with high-grade endometrial cancer.
Methods: This is an IRB-approved, multi-institutional cohort study of patients with clinically early-stage, high-grade endometrial cancer who underwent comprehensive surgical staging. Records were reviewed for demographic, pathologic, and treatment data. Nodal involvement and recurrence as a function of TS and location were estimated with odds ratios and hazard ratios.
Results: From 2005 to 2012, 208 patients were identified. Of these, 188 patients had tumor location and 183 had TS reported. There were 75 endometrioid (36.1%), 35 serous (16.8%), 12 clear cell (5.8%), and 26 carcinosarcoma (12.5%) cases, and 60 (28.8%) undifferentiated or mixed histologies. There were 55 recurrences (median follow up 17.2 mo). LUS tumors were associated with pelvic and para-aortic nodal disease (OR 3.83, 95% CI 1.70-8.60, p<0.01, OR 5.13, 95% CI 1.96-13.45, p<0.01). TS ≥ 2 cm was associated with pelvic nodal disease (27.4% vs. 0%, p=0.01; OR 10.00, p=0.01). Neither TS nor LUS location was independently associated with recurrence.
Conclusions: In high-grade endometrial cancers, tumor involvement of the LUS and TS>2 cm was associated with pelvic nodal disease, and LUS involvement was also significantly associated with para-aortic nodal disease. There was no association between LUS involvement or TS>2 cm and recurrence.
(© 2013.)
Databáze: MEDLINE
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