| Autor: |
Wyluda E; Department of Internal Medicine, Penn State Milton S. Hershey Medical Center , Hershey, PA, USA., Baquero G, Lamparella N, Abendroth C, Drabick J |
| Jazyk: |
angličtina |
| Zdroj: |
Rare tumors [Rare Tumors] 2013 Sep 26; Vol. 5 (3), pp. e46. Date of Electronic Publication: 2013 Sep 26 (Print Publication: 2013). |
| DOI: |
10.4081/rt.2013.e46 |
| Abstrakt: |
Epithelioid angiomyolipomas (EAMLs) are rare mesenchymal tumors whose malignant variant is extremely uncommon and highly aggressive. Treatment strategies include chemo radiation, transcatheter arterial embolization and surgical resection, which has remained the mainstay treatment. Targeted therapies including mammalian target of rapamycin (mTOR) inhibitors such as Temsirolimus may offer some hope for progressive malignant EAMLs that are not amenable to other treatment modalities. We report a fatal case in a young female who presented with rapidly progressive metastatic EAML that did not respond to mTOR therapy. The literature has shown reduction in tumor burden with the use of mTOR inhibitors, but unfortunately due to the rarity of malignant EAML, a meaningful approach to treatment remains challenging. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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