Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation.
| Autor: | Makhija IK; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India., Shreedhara CS, Ram HN |
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| Jazyk: | angličtina |
| Zdroj: | Pharmacognosy research [Pharmacognosy Res] 2013 Oct; Vol. 5 (4), pp. 306-8. |
| DOI: | 10.4103/0974-8490.118824 |
| Abstrakt: | Background: Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. Objective: The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. Materials and Methods: The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Results: Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). Conclusion: From the above results, it has been justified that SPC can be used to treat allergic disorders. |
| Databáze: | MEDLINE |
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