An international multicenter study comparing arrhythmia prevalence between the intracardiac lateral tunnel and the extracardiac conduit type of Fontan operations.

Autor:	Balaji S; Department of Pediatrics, Oregon Health & Science University, Portland, Ore., Daga A; Department of Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pa., Bradley DJ; Department of Cardiology, CS Mott Children's Hospital, Ann Arbor, Mich., Etheridge SP; Department of Cardiology, Primary Children's Medical Center and University of Utah, Salt Lake City, Utah., Law IH; Department of Pediatrics, University of Iowa, Iowa City, Iowa., Batra AS; Department of Pediatrics, University of California, Irvine, Calif., Sanatani S; Department of Cardiology, Children's Hospital, Vancouver, British Columbia, Canada., Singh AK; Department of Cardiology, Children's Hospital of Wisconsin, Milwaukee, Wis., Gajewski KK; Department of Pediatrics, Medical University of South Carolina, Charleston, SC., Tsao S; Department of Cardiology, Children's Memorial Hospital, Chicago, Ill., Singh HR; Department of Cardiology, Children's Hospital of Michigan, Detroit, Mich., Tisma-Dupanovic S; Department of Cardiology, Mercy Children's Hospital, Kansas City, Mo., Tateno S; Department of Pediatric Cardiology, Children's Hospital & Cardiovascular Center, Chiba, Japan., Takamuro M; Department of Pediatric Cardiology, Children's Hospital & Cardiovascular Center, Chiba, Japan., Nakajima H; Department of Pediatric Cardiology, Hokkaido Medical Center, Hokkaido, Japan., Roos-Hesselink JW; Department of Cardiology, Erasmus University, Rotterdam, The Netherlands., Shah M; Department of Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pa. Electronic address: shahm@email.chop.edu.
Jazyk:	angličtina
Zdroj:	The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2014 Aug; Vol. 148 (2), pp. 576-81. Date of Electronic Publication: 2013 Oct 27.
DOI:	10.1016/j.jtcvs.2013.08.070
Abstrakt:	Objective: The study objective was to determine whether the extracardiac conduit Fontan confers an arrhythmia advantage over the intracardiac lateral tunnel Fontan. Methods: This multicenter study of 1271 patients compared bradyarrhythmia (defined as need for pacing) and tachyarrhythmia (defined as needing antiarrhythmic therapy) between 602 patients undergoing the intracardiac Fontan and 669 patients undergoing the extracardiac Fontan. The median age at the time of the Fontan procedure was 2.1 years (interquartile range, 1.6-3.2 years) for the intracardiac group and 3.0 years (interquartile range, 2.4-3.9) for the extracardiac group (P < .0001). The median follow-up was 9.2 years (interquartile range, 5-12.8) for the intracardiac group and 4.7 years (interquartile range, 2.8-7.7) for the extracardiac group (P < .0001). Results: Early postoperative (<30 days) bradyarrhythmia occurred in 24 patients (4%) in the intracardiac group and 73 patients (11%) in the extracardiac group (P < .0001). Early postoperative (<30 days) tachyarrhythmia occurred in 32 patients (5%) in the intracardiac group and 53 patients (8%) in the extracardiac group (P = not significant). Late (>30 days) bradyarrhythmia occurred in 105 patients (18%) in the intracardiac group and 63 patients (9%) in the extracardiac group (P < .0001). Late (>30 days) tachyarrhythmia occurred in 58 patients (10%) in the intracardiac group and 23 patients (3%) in the extracardiac group (P < .0001). By multivariate analysis factoring time since surgery, more patients in the extracardiac group had early bradycardia (odds ratio, 2.9; 95% confidence interval, 1.8-4.6), with no difference in early tachycardia, late bradycardia, or late tachycardia. Conclusions: Overall arrhythmia burden is similar between the 2 groups, but the extracardiac Fontan group had a higher incidence of early bradyarrhythmias. There was no difference in the incidence of late tachyarrhythmias over time between the 2 operations. Therefore, the type of Fontan performed should be based on factors other than an anticipated reduction in arrhythmia burden from the extracardiac conduit. (Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.)
Databáze:	MEDLINE
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