Time trends in T3 to T4 laryngeal cancer: a population-based long-term analysis.

Autor: Reizenstein JA; Department of Oncology, Örebro University Hospital, Örebro, Sweden., Holmberg L, Bergqvist M, Linder A, Ekman S, Lödén B, Holmqvist M, Hellström K, von Beckerath M, Blomquist E, Bergström SN
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2014 Dec; Vol. 36 (12), pp. 1727-31. Date of Electronic Publication: 2014 Jan 29.
DOI: 10.1002/hed.23524
Abstrakt: Background: A decline in laryngectomies and survival in laryngeal cancer has been reported, especially among patients with advanced tumors.
Methods: Of 1058 patients with laryngeal cancer diagnosed from 1978 to 2007 in the Uppsala-Örebro region in Sweden, 263 T3 to T4 tumors treated with curative intent were studied retrospectively. Two time periods were defined, 1978 to 1992 and 1993 to 2007.
Results: Glottic tumors decreased constituting 68.6% of cases in 1978 to 1992 and 47.9% in 1993 to 2007. Laryngectomies were performed in 38.8% and 34.5% in the corresponding time periods. The use of laryngectomy was not strongly prognostic. A decline in overall survival (OS) over time could only be identified for the first year of follow-up. Chemotherapy was only used in a minority of cases.
Conclusion: The marked decrease of glottic site may mark a shift in etiology. Laryngectomy was not strongly associated with improved survival. The absence of improved survival calls for intensified research.
(© 2014 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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