Asymmetry in primary auditory cortex activity in tinnitus patients and controls.

Autor: Geven LI; Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands; Graduate School of Medical Sciences, Research School of Behavioral and Cognitive Neurosciences, University of Groningen, P.O. Box 196, 9700 AD Groningen, The Netherlands. Electronic address: l.i.geven@umcg.nl., de Kleine E; Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands; Graduate School of Medical Sciences, Research School of Behavioral and Cognitive Neurosciences, University of Groningen, P.O. Box 196, 9700 AD Groningen, The Netherlands., Willemsen AT; Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands., van Dijk P; Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands; Graduate School of Medical Sciences, Research School of Behavioral and Cognitive Neurosciences, University of Groningen, P.O. Box 196, 9700 AD Groningen, The Netherlands.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2014 Jan 03; Vol. 256, pp. 117-25. Date of Electronic Publication: 2013 Oct 23.
DOI: 10.1016/j.neuroscience.2013.10.015
Abstrakt: Tinnitus is a bothersome phantom sound percept and its neural correlates are not yet disentangled. Previously published papers, using [(18)F]-fluoro-deoxyglucose positron emission tomography (FDG-PET), have suggested an increased metabolism in the left primary auditory cortex in tinnitus patients. This unilateral hyperactivity has been used as a target in localized treatments such as transcranial magnetic stimulation. The purpose of the current study was to test whether left-sided hyperactivity in the auditory cortex is specific to tinnitus or is a general characteristic of the auditory system unrelated to tinnitus. Therefore, FDG-PET was used to measure brain metabolism in 20 tinnitus patients and to compare their results to those in 19 control subjects without tinnitus. In contrast to our expectation, there was no hyperactivity associated with tinnitus. Nevertheless, the activity in the left primary auditory cortex was higher than in the right primary auditory cortex, but this asymmetry was present in both tinnitus patients and control subjects. In contrast, the lateralization in secondary auditory cortex was opposite, with higher activation in the right hemisphere. These data show that hemisphere asymmetries in the metabolic resting activity of the auditory cortex are present, but these are not associated with tinnitus and are a normal characteristic of the normal brain.
(Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: