| Autor: |
Nankar SA, Prajapati JS, Pande AH; Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, (Mohali)-160 062, Punjab, India. apande@niper.ac.in. |
| Jazyk: |
angličtina |
| Zdroj: |
Protein and peptide letters [Protein Pept Lett] 2014; Vol. 21 (2), pp. 101-7. |
| DOI: |
10.2174/09298665113206660065 |
| Abstrakt: |
Apolipoprotein-derived peptides have emerged as a potential candidate for the treatment of various inflammatory disease conditions. These peptides bind to pro-inflammatory lipids and inhibit their inflammatory functions. Lysophosphatidylcholine (LPC) is a potent pro-inflammatory lipid and increased level of circulating LPC plays a major role in various acute and chronic inflammatory conditions. In this report we examined the effect of peptides derived from the C-terminal domain of human apolipoprotein E on the properties of LPC. Our results show that the peptides (E8, E10 and E11) bind to LPC and inhibit LPC-induced up-regulation of pro-inflammatory markers in human leukocytes. The results suggest that these peptides can be used as an anti-inflammatory agent in inflammatory conditions in which increased level of LPC is a culprit. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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