| Autor: |
Nunoya J; Lineberger Comprehensive Cancer Center., Washburn ML, Kovalev GI, Su L |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of infectious diseases [J Infect Dis] 2014 Apr 01; Vol. 209 (7), pp. 1039-44. Date of Electronic Publication: 2013 Oct 16. |
| DOI: |
10.1093/infdis/jit548 |
| Abstrakt: |
Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis C virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. Here, we report that regulatory T (Treg) cells prevent liver immunopathogenesis during HIV-1 infection in a humanized mouse model. In the absence of Treg cells, HIV-1 infection induced liver fibrosis associated with hepatic stellate cell activation, hepatitis, and liver injury. Our findings provide new insight linking Treg cells and liver immunopathogenesis during HIV-1 infection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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