Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.
| Autor: | Salzberg Y; Department of Genetics, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA., Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M, Kaprielian Z, Bülow HE |
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| Jazyk: | angličtina |
| Zdroj: | Cell [Cell] 2013 Oct 10; Vol. 155 (2), pp. 308-20. |
| DOI: | 10.1016/j.cell.2013.08.058 |
| Abstrakt: | Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"-like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously. (Copyright © 2013 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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