Effectiveness of novel 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazole derivatives against promastigotes and amastigotes of Leishmania amazonensis.

Autor: dos Santos Faiões V; Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21040-900, Brazil., Leon LL, Canto-Cavalheiro MM, Torres-Santos EC, Bernardino AM, Vegi PF, dos Santos MS
Jazyk: angličtina
Zdroj: Chemical biology & drug design [Chem Biol Drug Des] 2014 Mar; Vol. 83 (3), pp. 272-7. Date of Electronic Publication: 2013 Oct 30.
DOI: 10.1111/cbdd.12235
Abstrakt: In this research, a series of substituted 5-(5-amino-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles were synthesized and evaluated for in vitro antileishmanial activity. Among the derivatives, examined compounds 3b and 3l exhibited promising activity against promastigotes and amastigotes forms of Leishmania amazonensis. The cytotoxicity of these compounds was evaluated on murine cells, giving access to the corresponding selectivity index (SI).
(© 2013 John Wiley & Sons A/S.)
Databáze: MEDLINE
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