| Autor: |
Siogkas PK, Papafaklis MI, Sakellarios AI, Stefanou KA, Bourantas CV, Athanasiou LM, Bellos CV, Exarchos TP, Naka KK, Michalis LK, Parodi O, Fotiadis DI |
| Jazyk: |
angličtina |
| Zdroj: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2013; Vol. 2013, pp. 3885-8. |
| DOI: |
10.1109/EMBC.2013.6610393 |
| Abstrakt: |
Cardiovascular disease is one of the primary causes of morbidity and mortality around the globe. Thus, the diagnosis of critical lesions in coronary arteries is of utmost importance in clinical practice. One useful and efficient method to assess the functional severity of one or multiple lesions in a coronary artery is the calculation of the fractional flow reserve (FFR). In the current work, we present a method which allows the calculation of the FFR value computationally, without the use of a pressure wire and the induction of hyperemia, using intravascular ultrasound (IVUS) and biplane angiography images for three-dimensional (3D) coronary artery reconstruction and measurements of the volumetric flow rate derived from angiographic sequences. The simulated FFR values were compared to the invasively measured FFR values in 7 cases, presenting high correlation (r=0.85) and good agreement (mean difference=0.002). FFR assessment without employing a pressure wire and the induction of hyperemia is feasible using 3D reconstructed coronary artery models from angiographic and IVUS data coupled with computational fluid dynamics. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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