| Autor: |
Kotby AA; Faculty of Medicine, Pediatric Department, Ain Shams University, Abbasseya Square, Cairo 11566, Egypt., El-Shahed GS, Elmasry OA, El-Hadidi IS, El Shafey RN |
| Jazyk: |
angličtina |
| Zdroj: |
ISRN pediatrics [ISRN Pediatr] 2013 Sep 11; Vol. 2013, pp. 970394. Date of Electronic Publication: 2013 Sep 11 (Print Publication: 2013). |
| DOI: |
10.1155/2013/970394 |
| Abstrakt: |
Background. Rheumatic heart disease (RHD) is a leading cause of heart failure in children and young adults worldwide. B-type natriuretic peptide (BNP) is a useful marker of critical pediatric heart disease, and its N-terminal peptide, NT-proBNP, is elevated in congenital and acquired heart disease in children. Aim. To measure NT-proBNP levels as a marker of carditis in children with acute rheumatic carditis, as compared to children with quiescent RHD and healthy controls. Methods. 16 children with acute rheumatic carditis, 33 children with quiescent RHD, and a cohort of 30 healthy children were studied. Transthoracic echocardiography was performed to assess valve and cardiac function. Tissue Doppler echocardiography was performed for E/E' (ratio between mitral inflow E wave and lateral mitral annulus E' wave) and systolic strain. Results. NT-proBNP levels were significantly higher in children with acute rheumatic carditis and dropped with its resolution. Strain and E/E' values were comparable among the three groups. Conclusion. NT-proBNP is significantly elevated in children with acute rheumatic carditis in the acute stage compared to children with quiescent RHD and healthy subjects, in the presence of comparable echocardiographic indices of LV systolic and diastolic function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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