Synthesis and characterization of potential dimers of gatifloxacin - an antibacterial drug.
| Autor: | Garaga S; Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran (V), Sangareddy (M), Medak Dist., Hyderabad - 502 329, Andhra Pradesh, India. ; Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam - 530 003, Andhra Pradesh, India., Raghava Reddy AV, Prabahar KJ, Korupolu RB, Sanasi PD |
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| Jazyk: | angličtina |
| Zdroj: | Scientia pharmaceutica [Sci Pharm] 2013 Feb 18; Vol. 81 (3), pp. 651-62. Date of Electronic Publication: 2013 Feb 18 (Print Publication: 2013). |
| DOI: | 10.3797/scipharm.1212-21 |
| Abstrakt: | Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin (metabolite). |
| Databáze: | MEDLINE |
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