| Autor: |
Kulkarni RR; a Division of Organic Chemistry, CSIR-National Chemical Laboratory , Pune 411008 , India., Tupe SG, Gample SP, Chandgude MG, Sarkar D, Deshpande MV, Joshi SP |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2014; Vol. 28 (4), pp. 245-50. Date of Electronic Publication: 2013 Oct 07. |
| DOI: |
10.1080/14786419.2013.843178 |
| Abstrakt: |
From the red coloured extract (Kamala) prepared through acetone extraction of the fresh whole uncrushed fruits of Mallotus philippinensis, one new dimeric chalcone (1) along with three known compounds 1-(5,7-dihydroxy-2,2,6-trimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one (2), rottlerin (3) and 4'-hydroxyrottlerin (4) were isolated. The structure of compound 1 was elucidated by 1D and 2D NMR analyses that included HSQC, HMBC, COSY and ROESY experiments along with the literature comparison. Compounds 1-4 were evaluated for antifungal activity against different human pathogenic yeasts and filamentous fungi. The antiproliferative activity of the compounds was evaluated against Thp-1 cell lines. Compounds 1 and 2 both exhibited IC50 of 8, 4 and 16 μg/mL against Cryptococcus neoformans PRL518, C. neoformans ATCC32045 and Aspergillus fumigatus, respectively. Compound 4, at 100 μg/mL, showed 54% growth inhibition of Thp-1 cell lines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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