Co-delivery of drug and DNA from cationic dual-responsive micelles derived from poly(DMAEMA-co-PPGMA).
| Autor: | Loh XJ; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Singapore. Electronic address: XianJun_Loh@scholars.a-star.edu.sg., Ong SJ, Tung YT, Choo HT |
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| Jazyk: | angličtina |
| Zdroj: | Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2013 Dec 01; Vol. 33 (8), pp. 4545-50. Date of Electronic Publication: 2013 Jul 17. |
| DOI: | 10.1016/j.msec.2013.07.011 |
| Abstrakt: | The synthesis and gene transfection efficiency of a series of amphiphilic copolymers with poly(dimethylaminoethyl methacrylate) (PDMAEMA), and poly(propylene glycol methacrylate) (PPGMA) segments is reported. The hydrophobic PPGMA interior allows a cell-sensitizing drug such as paclitaxel to be incorporated while the cationic and hydrophilic PDMAEMA corona allows the complexation of anionic DNA to form a nano-sized polyplex. These drug-encapsulated copolymers display excellent gene transfection efficiency as compared to PEI or PDMAEMA homopolymers. (© 2013.) |
| Databáze: | MEDLINE |
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