| Autor: |
Alfimova MV; Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva., Golimbet VE, Korovaĭtseva GI, Aksenova EV, Lezheĭko TV, Abramova LI, Kolesina NIu, Anua IM, Savel'eva TM |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2013; Vol. 113 (8), pp. 50-6. |
| Abstrakt: |
To evaluate a role of dopamine transmission in the theory of mind (ToM) dysfunction in schizophrenia, authors studied the association of ToM with COMT and DRD2 gene polymorphisms in 209 patients with schizophrenia and 172 healthy people. All subjects performed second-order false belief (FB2) and faux pas stories. The association between the COMT Val158Met polymorphism and performance on FB2 was found. The association was sex-specific. The worse performance was associated with a Met allele in female patients and with the ValVal genotype in male ones. A correlation analysis of the COMT Val158Met polymorphism, performance on FB2 task, neurocognitive and clinical symptoms suggests that in female patients the association was modified, in part, by the higher stress sensitivity caused by the severity of clinical symptoms and its consequences for cognitive functioning. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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