Reversible inhibition of human acetylcholinesterase by methoxypyridinium species.

Autor: Topczewski JJ; Department of Chemistry, The University of Iowa, Iowa City, IA 52242, United States., Lodge AM, Yasapala SN, Payne MK, Keshavarzi PM, Quinn DM
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Nov 01; Vol. 23 (21), pp. 5786-9. Date of Electronic Publication: 2013 Sep 08.
DOI: 10.1016/j.bmcl.2013.09.008
Abstrakt: The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. Currently no antidote is known that resurrects the phosphyl-AChE complex once aging has occurred. This report characterizes the affinities of over 30 new AChE inhibitors which could act as resurrecting agents for the aged AChE-OP adduct.
(Copyright © 2013. Published by Elsevier Ltd.)
Databáze: MEDLINE
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