| Autor: |
Jemaa AB; a Unit of Immunology and Microbiology Environmental and Carcinogenesis (IMEC), University of Carthage , Zarzouna , Tunisia., Bouraoui Y, Sallami S, Banasr A, Nouira Y, Oueslati R |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of immunoassay & immunochemistry [J Immunoassay Immunochem] 2014; Vol. 35 (1), pp. 48-59. |
| DOI: |
10.1080/15321819.2013.792830 |
| Abstrakt: |
Prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) measured in serum are not fully satisfactory as biomarkers of prostate cancer (PC). Results obtained in this article indicated that PSMA/PSA ratio evaluated by immunohistochemistry in normal prostate (NP), benign prostatic hyperplasia (BPH), and PC at the individual level could be a useful tool for diagnosis and prognosis of PC. PSMA and PSA were equally expressed in NP and the PSMA/PSA ratio was 1.22 ± 0.15. Data also indicated that PSMA/PSA ratio fluctuates in BPH and PC compared to NP. In BPH, the PSMA/PSA ratio was around 0.47 ± 0.02, whereas it's significantly increased in PC, about 4.95 ± 0.83. In parallel, the highest PSMA/PSA ratio was associated with high intratumoral angiogenesis in PC patients with (PSMA+,PSA+) profile. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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