| Autor: |
Flynn GA; Merrell Dow Research Institute, Cincinnati, Ohio 45215., Ash RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1990 Jan 30; Vol. 166 (2), pp. 673-80. |
| DOI: |
10.1016/0006-291x(90)90862-h |
| Abstrakt: |
A novel route to activated phenolic sulfoxide analogs of sparsomycin has been developed. These analogs display an enhanced "preincubation effect" as inhibitors of peptide-bond formation. This time-dependent component of inhibition, which is postulated to result from an enzyme-mediated Pummerer rearrangement, is the dominant route to inhibition in these activated analogs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
