Application of [18F]FDG in radiolabeling reactions using microfluidic technology.

Autor: Bouvet VR; Department of Oncology, University of Alberta, Edmonton, AB, Canada. wuest@ualberta.ca., Wuest F
Jazyk: angličtina
Zdroj: Lab on a chip [Lab Chip] 2013 Nov 21; Vol. 13 (22), pp. 4290-4.
DOI: 10.1039/c3lc50797a
Abstrakt: Radiolabeling of peptides with the short-lived positron emitter fluorine-18 is usually a challenging endeavour. Conventional radiolabeling reactions mostly require fairly large amounts of peptides as labeling precursors, and extensive synthesis times. Intrinsic advantages of microfluidic technology permit to overcome these hurdles. Herein, we describe how microfluidic technology combined with [(18)F]FDG as readily available PET radiotracer allows for fast and high yielding radiolabeling reactions of peptides with fluorine-18.
Databáze: MEDLINE