| Autor: |
Panahi Y; Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Molla-Sadra Avenue, PO Box 19945/581, Vanak Sqare, Tehran, Iran. yunespanahi@yahoo.com, Davoudi SM, Beiraghdar F, Amiri M, Saadat A, Marzony ET, Naghizadeh MM, Sahebkar A |
| Jazyk: |
angličtina |
| Zdroj: |
Skinmed [Skinmed] 2013 Jul-Aug; Vol. 11 (4), pp. 205-9. |
| Abstrakt: |
Inflammation is a key component in the pathogenesis of sulfur mustard (SM)-induced skin complications. Here, the levels of interleukin (IL) -2, IL-4, IL-6, and IL-10 were evaluated in patients with chronic SM-induced complications. Seventy-four serum samples were collected from SM-injured veterans (SM group; n = 37) and nonchemically injured patients (control group; n = 37) with skin pruritus. The levels of IL-2, IL-4, IL-6, and IL-10 were evaluated by sandwich enzyme-linked immunosorbant assay technique in both nil and mitogen medium. No significant difference was found in pruritus score between SM (74.16 +/- 5.93) and control (74.48 +/- 6.15) groups (P > .05). The mean serum concentrations of IL-2 and IL-6 were found to be significantly elevated in the control compared with the SM group (P < .05). However, no significant difference was observed between the study groups regarding serum levels of IL-4 and IL-10 (P > .05). Serum IL-2 (in both SM and control groups) and IL-6 (in the control group) concentrations were significantly correlated with pruritus score while no significant association was found for IL-4 and IL-10. Serum concentrations of IL-2, IL-6, and IL-10 are significantly decreased in SM-exposed patients with chronic pruritus. Such alterations might represent a plausible mechanism for tissue damage and skin itching following SM exposure. Therefore, variation of ILs may also contribute to skin pruritus induced by SM. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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