Overestimation of nuclear matrix protein 22 in concentrated urine.

Autor: Joung JY; Center for Prostate Cancer, National Cancer Center, Goyang, Korea., Park S, Yoon H, Kwon WA, Cho IC, Seo HK, Chung J, Hwang SH, Lee CW, Lee KH
Jazyk: angličtina
Zdroj: Urology [Urology] 2013 Nov; Vol. 82 (5), pp. 1059-64. Date of Electronic Publication: 2013 Sep 14.
DOI: 10.1016/j.urology.2013.05.056
Abstrakt: Objective: To confirm the hypothesis that nuclear matrix protein 22 (NMP22) is overestimated in concentrated urine, we compared the NMP22 values measured at different dietary states.
Methods: We retrospectively reviewed 531 healthy subjects who had had abnormal urinary NMP22 values ≥ 10 U/mL at the first test and underwent a second NMP22 test within 2 weeks. The first NMP22 test was performed after overnight fasting, and the second was performed with no dietary restrictions. We compared the NMP22 values between the 2 measurements and investigated the relationship between the NMP22 value and urine specific gravity.
Results: At the second test, 504 subjects (94.9%) had a normal NMP22 value of <10 U/mL and only 27 subjects (5.1%) persistently had an abnormal NMP22 value of ≥ 10 U/mL. Both NMP22 and urine specific gravity at the first test were significantly higher than at the second test (P <.0001). Subjects with an abnormal NMP22 value tended to have a more concentrated urine with a greater urine specific gravity than did the subjects with a normal NMP22 value. This difference was significant in the subgroup undergoing bowel preparation for colonoscopy (P <.001).
Conclusion: NMP22 will be overestimated in concentrated urine after overnight fasting. When interpreting the NMP22 value, we should consider the overestimation of NMP22 in concentrated urine.
(Copyright © 2013 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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