Geographical and social influences on genetic diversity within the Egyptian population: analyses of Alu insertion polymorphisms.

Autor: Salem AH; Department of Anatomy, College of Medicine and Medical Sciences, Arabian Gulf University , PO Box 22979 Manama , Bahrain ., Bahri R, Jarjanazi H, Chaabani H
Jazyk: angličtina
Zdroj: Annals of human biology [Ann Hum Biol] 2014 Jan-Feb; Vol. 41 (1), pp. 61-6. Date of Electronic Publication: 2013 Sep 13.
DOI: 10.3109/03014460.2013.826734
Abstrakt: Background: The geographical location of Egypt at the crossroads of several major cultural areas between North Africa and the Middle East has contributed to its population history.
Aim: To analyse the genetic structure of the population living in two geographical parts of Egypt.
Subjects and Methods: A sample of 112 Egyptians from the North African part of Egypt (Ismailia sample) and a sample of 52 Egyptians from the Asian part Sinai, have been analysed using 10 Alu insertion polymorphisms.
Results: The results of the present study showed a significant genetic difference between the Sinai and Ismailia samples. The latter showed an evident genetic affinity with North African populations; whereas the Sinai sample was found to be genetically closer to the Middle East populations. The Sinai sample showed a low average heterozygosity, unlike that found in the Ismailia sample.
Conclusion: This study provides new insights into the genetic structure of the Egyptian population living in a land bridge between Africa and Asia. Results suggest a genetic discontinuity between the Sinai population and that of the North African part of Egypt. This discontinuity would have been maintained thanks to geo-climatic and social factors.
Databáze: MEDLINE
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