A home-based intervention to reduce depressive symptoms and improve quality of life in older African Americans: a randomized trial.

Autor:	Gitlin LN, Harris LF, McCoy MC, Chernett NL, Pizzi LT, Jutkowitz E, Hess E, Hauck WW
Jazyk:	angličtina
Zdroj:	Annals of internal medicine [Ann Intern Med] 2013 Aug 20; Vol. 159 (4), pp. 243-52.
DOI:	10.7326/0003-4819-159-4-201308200-00005
Abstrakt:	Background: Effective care models for treating older African Americans with depressive symptoms are needed. Objective: To determine whether a home-based intervention alleviates depressive symptoms and improves quality of life in older African Americans. Design: Parallel, randomized trial stratified by recruitment site. Interviewers assessing outcomes were blinded to treatment assignment. (ClinicalTrials.gov: NCT00511680). Setting: A senior center and participants' homes from 2008 to 2010. Patients: African Americans aged 55 years or older with depressive symptoms. Intervention: A multicomponent, home-based intervention delivered by social workers or a wait-list control group that received the intervention at 4 months. Measurements: Self-reported depression severity at 4 months (primary outcome) and depression knowledge, quality of life, behavioral activation, anxiety, function, and remission at 4 and 8 months. Results: Of 208 participants (106 and 102 in the intervention and wait-list groups, respectively), 182 (89 and 93, respectively) completed 4 months and 160 (79 and 81, respectively) completed 8 months. At 4 months, participants in the intervention group showed reduced depression severity (difference in mean change in Patient Health Questionnaire-9 score from baseline, -2.9 [95% CI, -4.6 to -1.2]; difference in mean change in Center for Epidemiologic Studies Depression Scale score from baseline, -3.7 [CI, -5.4 to -2.1]); improved depression knowledge, quality of life, behavioral activation, and anxiety (P < 0.001); and improved function (P = 0.014) compared with wait-list participants. More intervention than wait-list participants entered remission at 4 months (43.8% vs. 26.9%). After treatment, control participants showed benefits similar in magnitude to those of participants in the initial intervention group. Those in the initial intervention group maintained benefits at 8 months. Limitation: The study had a small sample, short duration, and differential withdrawal rate. Conclusion: A home-based intervention delivered by social workers could reduce depressive symptoms and enhance quality of life in most older African Americans. Primary Funding Source: National Institute of Mental Health.
Databáze:	MEDLINE
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