The diagnostic value of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase measurement in the sera of patients with endometrial cancer.

Autor:	Orywal K; Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15 A, PL 15-276, Bialystok, Poland. orywalk@umwb.edu.pl., Jelski W, Zdrodowski M, Szmitkowski M
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2013 Sep; Vol. 33 (9), pp. 3725-30.
Abstrakt:	Background/aim: The aim of this study was to investigate the potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for endometrial cancer. Patients and Methods: Serum samples were obtained from 40 women with endometrial cancer, 52 with myoma uteri and 52 healthy individuals. Class III, IV of ADH and total ADH activity was measured by a photometric method and class I, II ADH and ALDH activity, by a fluorometric method. Results: The total activity of ADH and ADH class I was significantly higher in the serum of patients with endometrial cancer than in healthy individuals and patients with myoma. The diagnostic sensitivity for ADH I was 69%, specificity 77%, positive predictive value and negative predictive value were 75% and 71% respectively. The area under curve for ADH I was 0.682 and for total ADH was 0.623. Conclusion: The results suggest a potential role of ADH I as a marker for endometrial cancer.
Databáze:	MEDLINE
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