Cytotoxic behavior and spectroscopic characterization of metal complexes of ethylacetoacetate bis(thiosemicarbazone) ligand.

Autor: El-Tabl AS; Chemistry Department, Faculty of Science, Menoufia University, Shebin-El-Kom, Egypt. Electronic address: asaeltabl@yahoo.com., El-wahed MM, Rezk AM
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2014 Jan 03; Vol. 117, pp. 772-88. Date of Electronic Publication: 2013 Apr 10.
DOI: 10.1016/j.saa.2013.04.014
Abstrakt: Reaction of Cr(III), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) ion with 2,4-dihydrazino-thioamido-1-ethoxybutane led to the formation of mono and binuclear complexes. These complexes have been characterized by elemental analyses, IR, UV-Vis spectra, magnetic moments, molar conductances, (1)H NMR and mass spectra (ligand and its Zn(II) complex), thermal analyses (DTA and TGA) and ESR measurements. The IR data suggest the involvement of sulfur and azomethane nitrogen atoms in coordination to the central metal ion .The Molar conductances of the complexes in DMF are commensurate with their non-ionic character. The ESR spectra of Cu(II) complexes show axial type symmetry (d(x2-y2)) ground state with covalent bond character. On the basis of spectral studies, octahedral or tetrahedral geometry has been assigned to the metal complexes. Complexes have been tested invitro against tumor cells and number of microorganisms in order to assess their antitumor and antimicrobial properties.
(Copyright © 2013. Published by Elsevier B.V.)
Databáze: MEDLINE
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