[Intranasal co-administration of recombinant streptococcus group B polypeptides and influenza deltaNS1 vaccine].

Autor: Shurygina AP, Leont'eva GF, Grabovskaia KB, Gupalova TV, Koroleva IV, Kramskaia TA, Kiselev OI, Egorov AIu, Suvorov AN
Jazyk: ruština
Zdroj: Voprosy virusologii [Vopr Virusol] 2013 May-Jun; Vol. 58 (3), pp. 28-31.
Abstrakt: In the present work, the immunoadjuvant properties of the influenza deltaNS1 vaccine virus after intranasal administration in combination with recombinant GBS polypeptides was tested in mice. According to our data, co-administration of recombinant GBS polypeptides and influenza deltaNS1 vaccine resulted in the increase in the immunogenicity and protective efficacy of bacterial proteins. Combined vaccination with the GBS polypeptides and influenza deltaNS1 vaccine has a potential to be used not only for prophylaxis infections caused by SGB, but also for prevention of the bacterial complications of influenza.
Databáze: MEDLINE