Trafficking of NMDA receptors during status epilepticus: therapeutic implications.

Autor: Wasterlain CG; Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System-West Los Angeles, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, U.S.A. wasterla@ucla.edu, Naylor DE, Liu H, Niquet J, Baldwin R
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2013 Sep; Vol. 54 Suppl 6, pp. 78-80.
DOI: 10.1111/epi.12285
Abstrakt: We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.
(Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.)
Databáze: MEDLINE
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