Receptor trafficking hypothesis revisited: plasticity of AMPA receptors during established status epilepticus.

Autor: Rajasekaran K; Department of Neurology, University of Virginia, Health Sciences Center, Charlottesville, VA, U.S.A., Joshi S, Kozhemyakin M, Todorovic MS, Kowalski S, Balint C, Kapur J
Jazyk: angličtina
Zdroj: Epilepsia [Epilepsia] 2013 Sep; Vol. 54 Suppl 6, pp. 14-6.
DOI: 10.1111/epi.12266
Abstrakt: Status epilepticus (SE) is associated with a dynamic plasticity of postsynaptic neurotransmitter receptors. The plasticity of AMPA receptor (AMPAR)-mediated glutamatergic transmission during established SE (ESE), after development of benzodiazepine resistance, was evaluated. There was increased frequency and inward rectification of AMPAR-mediated excitatory postsynaptic currents at Schaffer collateral - CA1 pyramidal neuron synapses during ESE. Surface expression of the GluA1 subunit increased, and this was a consequence of N-methyl-d-aspartate receptor activation. Further, diminishing glutamate release by activation of somatostatin receptors prevented SE. These studies suggest that AMPAR-mediated glutamatergic transmission is strengthened during ESE.
(Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.)
Databáze: MEDLINE
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